Technology Overview

This technology evaluated more than 70 relevant SNPs for their clinical utility in determining inter-individual variability in response to a dose of morphine and opioids. By confirming many of the previous genotype-phenotype associations reported in literature, our researchers have found several strong novel associations with clinical outcome measures, gene-gene interactions and gene-non-genetic factor interactions which are critical in connecting clinically important dots in predicting and personalizing care and reducing adverse clinical and economical outcomes in children and adults.

Applications

• Rapid point-of-care genotyping for personalized pain management.
  
• Opioid pain research

Advantages

• Personalized dosing of opioids for better safety.
  
• More effective acute pain management.
  
• Proactive risk identification and prevention of opioid-related adverse events.
  
• Potential for savings to the healthcare system.

Market Overview

In the US alone, every year more than 5 million children and more than 25 million adults undergo painful surgery. Inadequate pain relief and serious side effects from perioperative opioids occur frequently in up to 50% of patients.

Investigator Overview

Senthil Sadhasivam, MD, MPH, Division of Pediatric Anesthesia