Microbiota-derived retinoid boosts immunity
Probiotic bacteria strains increase infection resistance.
Intestinal epithelial and immune cells have been found to play an important role in protecting the gut from pathogenic infection. Cincinnati Children's innovators identified two bacterial strains that precisely interact with the gut microbiome, triggering the production of retinoic acid. This metabolite effectively enhances host intestinal defense responses. These newly identified bacteria can be incorporated into a supplement, which can be administered individually, in combination, or alongside Vitamin A. This supplementation may prompt cells to release retinoic acid, enhancing the immune system.
This can be formulated as a probiotic gut health supplement that delivers therapeutic benefit to the gut microbiome interface.
Recently discovered strains of probiotic bacteria interact with the gut microbiome in a unique way producing the release of retinoic acid and delivering an immunity boost to the host.
The global probiotics market is estimated to have a value of approximately 73 billion US$ in 2023. (Reports, 2023) The incidence of pediatric gastroenteritis (ages 0-4) is approximately 13.5% according to the CAGE Study (Community Acute Gastroenteritis Study ).
Theresa Alenghat, Ph.D. Asst. Professor, Division of Immunobiology