Innovation Ventures

Partnering Opportunities

• Pulmonology

  Method of Treating Cystic Fibrosis with Src Kinase Inhibitors

  Scientists have shown that src kinase inhibitors are effective at treating CF patients with a frame deletion of F508 in the CFTR gene.

• Metabolic disorder

  Autologous cell and gene therapy for Gaucher Disease

  Therapy for neuronopathic Gaucher Disease using gene therapy and a specialized neuronal lineage iPS cell that facilitates entry to and engraftment in the brain.

• "Oncology, Inflammation"

  Targeted inhibition of UBE2N as a therapeutic approach in myeloid malignancies

  Pharmacologic and genetic inhibition of UBE2N suppresses the function and viability of MDS/AML cells lines and patient samples. A commercially available and a novel compound has been identified.

• Dermatology

  Rapid reliable method for collection of keratinocyte RNA and DNA samples from children.

  Rapid reliable method for collection of keratinocyte RNA, DNA, microbiome, proteins, lipids, and metabolites.

• Oncology & Pulmonology

  RCM-1 Compound to Treat Cancers and Pulmonary Indications

  Increased FOXM1 is associated with proliferative diseases such as cancer and pulmonary diseases. A small molecule FOXM1 inhibitor has been identified.

• Pulmonology

  A Treatment for Emphysema and Lung Disease with Cela 1 Inhibition

  A recombinant antibody has been developed for Cela1, which is important in diseases of stretch-induced distal airspace destruction such as emphysema.

• Surgery

  Spherical implant to improve surgical outcomes for patients with esophageal Atresia

  Spheric endo-luminal traction device helps improve surgical outcomes for individuals with long-gap esophageal atresia

• Neurology

  Using Dantrolene to Treat Neuronopathic Gaucher Disease

  Dantrolene is an antagonist of ryanodine receptors (Ryrs) and blocks Ryr-mediated endoplasmic reticulum calcium release. It is an FDA-approved drug.

• Pharmacology

  Model-Informed Precision Dosing Platform

  Cloud-based, HIPAA-compliant clinical decision-support platform that brings pharmacometrics and model-informed precision dosing directly to the bedside.

• Drug Delivery & Formulation

  Dosing Algorithm for Inhibitors of Complement-Mediated Activity

  A validated algorithm to calculate when the next dose of an inhibitor of complement-mediated (C5) activity is required.